Authors:
Nina Kiseleva
For citation:
Kiseleva N. Mechanisms of the Antistress Effect of Thymus Peptides. Journal of Clinical Physiology and Pathology (JISCPP) 2025; 3 (2): 41-47.
Abstract:
The review presents the results of research conducted from 2008 to 2020 at the Department of Pharmacology of the Pediatric Faculty of the GBOU VPO RNIMU of the Ministry of Health of the Russian Federation, in the Laboratory of the Evolution of Memory Mechanisms of the Department of Higher Nervous Activity of the Faculty of Biology of the Lomonosov Moscow State University and in the Laboratory of Molecular Immunology of the Federal State Budgetary Scientific Institution «Research Institute of Physico-Chemical Medicine» of the FMBA of the Russian Federation. To understand the processes underlying the antistress effect of thymus peptide preparations (thymulin, tactivin, and the 5th fraction of thymosin), radioligand binding to the GABAA receptor, neurochemical studies, and experiments using non-selective opiate and serotonin receptor blockers have been conducted. Based on the data obtained, it is assumed that by triggering the cytokine cascade, thymus peptides increase the level of the inhibitory amino acids taurine and glycine, alter the balance of monoamines serotonin/norepinephrine in favor of the former and activate opioid neurons, which in turn limits the damaging effects of stress reactions.
Keywords:
stress, stress-limiting system, functional disorders, thymus, thymalin, tactivin, 5th fraction of thymosin.